3-(Bromomethyl)-5-fluoropyridine hydrobromide synthesis

Yield:-

Reaction Conditions:

with phosphorus tribromide in dichloromethane at 20;

Steps:

44
To a solution of (5-fluoropyridin-3-yl)methanol (430 mg, 3.4 mmol) in anhydrous dichloromethane (30 mL) was added dropwise phosphorus tribromide (650 μL, 6.8 mmol). The mixture was stirred at room temperature overnight. Dichloromethane was evaporated. The residue was dried in vacuo, affording 3-(bromomethyl)-5- fluoropyridine hydrobromide. The product was used without further purification.

References:

CHLORION PHARMA, INC.;UNIVERSITE LAVAL;ATTARDO, Giorgio;TRIPATHY, Sasmita WO2010/132999, 2010, A1 Location in patent:Page/Page column 103