3-(BROMOMETHYL)TETRAHYDRO-2H-PYRAN synthesis
- Product Name:3-(BROMOMETHYL)TETRAHYDRO-2H-PYRAN
- CAS Number:116131-44-3
- Molecular formula:C6H11BrO
- Molecular Weight:179.05
14774-36-8
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116131-44-3
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Yield:-
Reaction Conditions:
with tetrabutylammomium bromide;triphenylphosphine;2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane at 20; for 1 h;
Steps:
15 Intermediate 15.2: 3-(bromomethyl)tetrahydro-2H-pyran
[00175] At rt, to a suspension of 4,5-dichloro-3,6-dioxocyclohexa-1 ,4-diene-1 ,2- dicarbonitrile (1 .216 g, 5.356 mmol), TBAB (1 .727 mg, 5.356 mmol) and PPh3 (1 .405 g, 5.356 mmol) in DCM (15 mL) was added a solution of 15.1 (360 mg, 3.151 mmol) in DCM (10 mL) dropwise quickly. After addition, the reaction mixture turned to a brown solution and was stirred at rt for another 1 h. Then it was purified by column chromatography on silica gel (pH=8~9, eluent: PE/EA=10:1) directly to give crude title compound (140 mg, 25%) as a colorless oil.
References:
NOVARTIS AG;HE, Feng;DU-CUNY, Lei;XIAO, Qitao;XUN, Guoliang;ZHENG, Qiangang WO2017/149463, 2017, A1 Location in patent:Paragraph 00175
948007-45-2
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116131-44-3
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116131-44-3
67 suppliers
$58.00/100 mg