ChemicalBook CAS DataBase List 3-Bromomethylthiophene

3-Bromomethylthiophene synthesis

3synthesis methods

Product Name:3-Bromomethylthiophene
CAS Number:34846-44-1
Molecular formula:C5H5BrS
Molecular Weight:177.06

71637-34-8 Synthesis

71637-34-8
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$5.00/1g

34846-44-1
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$52.00/1 g

Yield:34846-44-1 100%

Reaction Conditions:

with phosphorus tribromide in dichloromethane at 20; for 16 h;Inert atmosphere;

Steps:

13; R
To a stirred solution of thiophen-3-ylmethanol (2 mmol, 0.29 g) in dry DCM (20 mL) under an inert atmosphere was added phosphorous tribromide (4 mmol, 0.38 mL). The reaction mixture was stirred at room temperature for 16 h, and then concentrated in vacuo and partitioned between saturated sodium bicarbonate solution and DCM. The layers were separated and the aqueous was extracted twice more with DCM. The combined organic layers were washed with brine, dried over MgSO₄and concentrated in vacuo to give a quantitative yield of 3-(bromomethyl)thiophene. ¹H NMR (CDCl₃): 7.09 (2H, m), 6.94 (1H, dd, J 4.9, 1.3 Hz), 4.33 (2H, s).

References:

BIOMARIN IGA LIMITED US2010/305120, 2010, A1 Location in patent:Page/Page column 52

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616-44-4 Synthesis