![](/CAS/GIF/1878-67-7.gif)
3-Bromophenylacetic acid synthesis
- Product Name:3-Bromophenylacetic acid
- CAS Number:1878-67-7
- Molecular formula:C8H7BrO2
- Molecular Weight:215.04
![3'-Bromoacetophenone](/CAS/GIF/2142-63-4.gif)
2142-63-4
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![3-Bromophenylacetic acid](/CAS/GIF/1878-67-7.gif)
1878-67-7
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$5.00/5g
Yield:1878-67-7 92.3%
Reaction Conditions:
Stage #1:1-(3-Bromophenyl)ethanone with 4-methyl-morpholine;sulfur for 14 h;Reflux;
Stage #2: with sulfuric acid;acetic acid in water at 20 - 30; for 6 h;Reflux;
Steps:
1.1 first stepPreparation of 3-bromo-phenylacetic acid (2)
In 1000ml three-necked flask of sublimed sulfur were added 24g (0.75mol), 100g3- bromoacetophenone (0.5mol) and 65.4g (0.75mol) morpholine was stirred at reflux for 14 hours. Cooling to 20 ~ 30 , stirring joined by glacial acetic acid 260ml, 75ml and 52ml distilled water mixed with concentrated sulfuric acid solution dubbed refluxing was continued for 6 hours. The reaction mixture was poured into ice water, stirring to brown solid precipitated was filtered. The solid was dissolved 300ml20% aqueous sodium hydroxide solution and filtered. The filtrate was placed in an ice bath, 2mol / L of hydrochloric acid to adjust pH = 1 ~ 2, crystallization, filtration, 60 dried to give 99.2g of yellow solid 2, a yield of 92.3%.
References:
Weihai Disu Pharmaceutical Co., Ltd.;Weihai Dijia Pharmaceutical Co., Ltd.;Liu, Qingchun;Chen, Huilai;Sun, Jian;Wang, Huabing;Meng, Cunzhi;Song, Gaofeng CN105348195, 2016, A Location in patent:Paragraph 0005; 0015
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31938-07-5
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![3-Bromophenylacetic acid](/CAS/GIF/1878-67-7.gif)
1878-67-7
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![ETHYL 2-(3-BROMOPHENYL)ACETATE](/CAS/GIF/14062-30-7.gif)
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$6.00/1g
![3-Bromophenylacetic acid](/CAS/GIF/1878-67-7.gif)
1878-67-7
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124-38-9
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![Benzaldehyde, 3-bromo-, hydrazone](/CAS/20210305/GIF/306773-37-5.gif)
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![3-Bromophenylacetic acid](/CAS/GIF/1878-67-7.gif)
1878-67-7
327 suppliers
$5.00/5g