ChemicalBook CAS DataBase List 3-BUTENAMIDE

3-BUTENAMIDE synthesis

6synthesis methods

Product Name:3-BUTENAMIDE
CAS Number:28446-58-4
Molecular formula:C4H7NO
Molecular Weight:85.1

109-75-1 Synthesis

109-75-1
155 suppliers
$9.00/1g

28446-58-4
26 suppliers
$109.90/5 mg

Yield: 100%

Reaction Conditions:

with Acetaldehyde oxime in methanol at 65; for 4 h;

Steps:

General procedure: A typical reaction was carried out in a 10 mL flask. Benzonitrile (2 mmol), Cu^II-4 Å (0.2 g), acetaldoxime (6 mmol) and MeOH (4 mL) were stirred at 65 °C for 4 h. The solid was filtered, washed with MeOH and the filtrate evaporated. The residue was subjected to GC-MS analysis and NMR spectroscopy. The filtered catalyst can be recycled after drying at about 150 °C for 1 h.

References:

Kiss, Árpád;Hell, Zoltán [Tetrahedron Letters,2011,vol. 52,# 45,p. 6021 - 6023] Location in patent:experimental part