3-BUTYN-1-YL CHLOROFORMATE 98 synthesis
2synthesis methods
- Product Name:3-BUTYN-1-YL CHLOROFORMATE 98
- CAS Number:190774-49-3
- Molecular formula:C5H5ClO2
- Molecular Weight:132.54
Yield:190774-49-3 100%
Reaction Conditions:
Stage #1: bis(trichloromethyl) carbonate;3-Butyn-1-ol in tetrahydrofuran at 0 - 20;
Stage #2: with pyridine in tetrahydrofuran at 0 - 20; for 2 h;
References:
D'Ascenzio, Melissa;Pugh, Kathryn M.;Konietzny, Rebecca;Berridge, Georgina;Tallant, Cynthia;Hashem, Shaima;Monteiro, Octovia;Thomas, Jason R.;Schirle, Markus;Knapp, Stefan;Marsden, Brian;Fedorov, Oleg;Bountra, Chas;Kessler, Benedikt M.;Brennan, Paul E. [Angewandte Chemie - International Edition,2019,vol. 58,# 4,p. 1007 - 1012][Angew. Chem.,2019,vol. 131,p. 1019 - 1024,6] Location in patent:supporting information
