ChemicalBook CAS DataBase List (3-(carbazole-9H)Phenyl)Pinacol ester

(3-(carbazole-9H)Phenyl)Pinacol ester synthesis

8synthesis methods

Product Name:(3-(carbazole-9H)Phenyl)Pinacol ester
CAS Number:870119-58-7
Molecular formula:C24H24BNO2
Molecular Weight:369.27

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Yield:870119-58-7 85%

Reaction Conditions:

with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in N,N-dimethyl-formamide at 150; for 20 h;Inert atmosphere;

Steps:

3 Synthesis Example 3: Synthesis of Intermediate I-3

Intermediate I-2 (100 g, 360 mmol) was dissolved in 1.0 L of dimethylformamide (DMF) under a nitrogen environment, and bis(pinacolato)diboron (110 g, 432 mmol), (1,1′-bis(diphenylphosphine)ferrocene)dichloropalladium (II) (2.94 g, 3.60 mmol), and potassium acetate (106 g, 1,080 mmol) were added thereto and then, heated and refluxed at 150° C. for 20 hours. When a reaction was complete, after adding water to the reaction solution, the mixture was filtered and dried in a vacuum oven. This obtained residue was separated and purified through flash column chromatography to obtain Intermediate I-3 (113 g, 85%). (0155) HRMS (70 eV, EI+): m/z calcd for C24H24BNO2: 369.1900, found: 369. (0156) Elemental Analysis: C, 78%; H, 7%

References:

US2021/130304,2021,A1 Location in patent:Paragraph 0153-0156

185112-61-2 Synthesis