3-chloro-2,4-dimethylaniline synthesis
- Product Name:3-chloro-2,4-dimethylaniline
- CAS Number:40625-24-9
- Molecular formula:C8H10ClN
- Molecular Weight:155.62
35113-96-3
12 suppliers
inquiry
40625-24-9
27 suppliers
inquiry
Yield:40625-24-9 71%
Reaction Conditions:
with iron;ammonium chloride in ethanol;water at 80; for 2 h;
Steps:
2 Step 2
To a solution of 2-chloro-1 ,3-dimethyl -4-nitrobenzene (2.10 g, 1 1 .3 mmol, 1 .00 eq) in ethanol (24.0 mL) and water (8.00 mL) was added ammonium chloride (6.05 g, 1 13 mmol, 10.0 eq) and Fe (3.79 g, 67.9 mmol, 6.00 eq). The reaction was stirred at 80°C for 2 h. The mixture was filtered, and the filtrate was concentrated under reduced pressure to give a residue. The residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 1 /0 to 3/1 ) to afford 3-chloro-2,4-dimethylaniline (1 .25 g, 8.03 mmol, 71 .0% yield) as light-yellow oil.
References:
WO2021/69705,2021,A1 Location in patent:Page/Page column 171-172
67083-28-7
59 suppliers
$56.00/100mg
40625-24-9
27 suppliers
inquiry
6781-98-2
155 suppliers
$9.00/5g
40625-24-9
27 suppliers
inquiry
