3-CHLORO-3',4'-DIFLUOROBENZHYDROL synthesis
- Product Name:3-CHLORO-3',4'-DIFLUOROBENZHYDROL
- CAS Number:844683-50-7
- Molecular formula:C13H9ClF2O
- Molecular Weight:254.66
737797-28-3
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844683-50-7
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$414.00/1g
Yield:844683-50-7 73%
Reaction Conditions:
Stage #1: (3,4-difluorophenyl)zinc bromidewith magnesium chloride in tetrahydrofuran;toluene at 20; for 2 h;Inert atmosphere;Negishi coupling reaction;
Stage #2: m-Chlorobenzaldehyde in tetrahydrofuran;toluene; for 6 h;Inert atmosphere;Negishi coupling reaction;
References:
Jin, Meng-Yi;Yoshikai, Naohiko [Journal of Organic Chemistry,2011,vol. 76,# 7,p. 1972 - 1978] Location in patent:experimental part