3-CHLORO-4-METHYLBENZAMIDE synthesis

4synthesis methods

Product Name:3-CHLORO-4-METHYLBENZAMIDE
CAS Number:24377-95-5
Molecular formula:C8H8ClNO
Molecular Weight:169.61

21423-81-4 Synthesis

21423-81-4
125 suppliers
$9.00/1g

24377-95-5
17 suppliers
$28.60/250mg

Yield:24377-95-5 100%

Reaction Conditions:

with Acetaldehyde oxime in methanol at 65; for 4 h;

Steps:

General procedure: A typical reaction was carried out in a 10 mL flask. Benzonitrile (2 mmol), Cu^II-4 ? (0.2 g), acetaldoxime (6 mmol) and MeOH (4 mL) were stirred at 65 °C for 4 h. The solid was filtered, washed with MeOH and the filtrate evaporated. The residue was subjected to GC-MS analysis and NMR spectroscopy. The filtered catalyst can be recycled after drying at about 150 °C for 1 h.

References:

Kiss, árpád;Hell, Zoltán [Tetrahedron Letters,2011,vol. 52,# 45,p. 6021 - 6023] Location in patent:experimental part