![](/CAS/20150408/GIF/109418-89-5.gif)
3-chloro-4-Methylthiobenzylchloride synthesis
- Product Name:3-chloro-4-Methylthiobenzylchloride
- CAS Number:109418-89-5
- Molecular formula:C8H8Cl2S
- Molecular Weight:207.12
![Formaldehyde](/CAS/GIF/50-00-0.gif)
50-00-0
846 suppliers
$10.00/25g
![2-CHLOROTHIOANISOLE](/CAS/GIF/17733-22-1.gif)
17733-22-1
113 suppliers
$11.00/5g
![3-chloro-4-Methylthiobenzylchloride](/CAS/20150408/GIF/109418-89-5.gif)
109418-89-5
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Yield:109418-89-5 39%
Reaction Conditions:
with hydrogenchloride;zinc(II) chloride in water at 50; for 21 h;Blanc Chloromethylation Reaction;
Steps:
1.a.1
A mixture of 2-chlorothioanisole (200 g, 1.26 mol, 1.00 eg.), paraformaldehyde (126 g, 4.20 mol, 3.33 eg.), ZnCl2 (75.6 g, 0.55 mol, 0.44 eg.) and hydrochloric acid (630 ml, 37% in H2O) was stirred at 500C for 21 h. The organic phase was removed, washed with water and distilled, which removed unconverted 2- chlorothioanisole (82.4 g, 0.52 mol, 41%). The remaining distillation bottoms consisted for the most part of 3-chloro-4-methylthiobenzyl chloride (123.6 g,
References:
WO2007/96034,2007,A1 Location in patent:Page/Page column 10-11