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3-chloro-4-(thiazol-2-ylmethoxy)aniline synthesis

2synthesis methods
2-((2-chloro-4-nitrophenoxy)methyl)thiazole

851545-78-3
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3-chloro-4-(thiazol-2-ylmethoxy)aniline

851545-79-4
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Yield:851545-79-4 96%

Reaction Conditions:

with hydrogen;zinc in ethanol; for 4 h;

Steps:

1.2

2. 30.7 g of the compound obtained above, add 0.65 g of zinc powder and 25 ml of ethanol.Hydrogen was added and reacted under pressure for 4h.After the reaction, the zinc powder was removed by filtration, and the solvent was distilled off under reduced pressure to obtain 26.6 g of white solid with a yield of 96%.

References:

CN111499622,2020,A Location in patent:Paragraph 0017; 0029; 0033; 0036