3-CHLORO-5-FLUOROPHENYLMAGNESIUM BROMIDE synthesis
- Product Name:3-CHLORO-5-FLUOROPHENYLMAGNESIUM BROMIDE
- CAS Number:480438-50-4
- Molecular formula:C6H3BrClFMg
- Molecular Weight:233.75
33863-76-2
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480438-50-4
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Yield:-
Reaction Conditions:
with iodine in tetrahydrofuran; for 1 h;Heating / reflux;Grignard Reaction;
Steps:
6.3
A 100 mL 3 -neck flask was placed under N2 and equipped with a condenser and an addition funnel. Magnesium (2.0 g, 83 mmol) were added, bromo-3-chloro- 5-fluoro benzene (15 g, 72.5 mmol) was taken up in dry THF (70 mL), and transferred to the addition funnel. The Grignard reaction was initiated with approximately 2 mL of the bromo-3-chloro -5-fluorobenzene solution and iodine. The remaining bromo-3-chloro-5-fluorobenzene solution was added and the reaction was refluxed 1 hour.
References:
WO2008/156817,2008,A2 Location in patent:Page/Page column 150-151