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ChemicalBook CAS DataBase List 3-CHLORO-5-FLUOROPHENYLMAGNESIUM BROMIDE
480438-50-4

3-CHLORO-5-FLUOROPHENYLMAGNESIUM BROMIDE synthesis

1synthesis methods
-

Yield:-

Reaction Conditions:

with iodine in tetrahydrofuran; for 1 h;Heating / reflux;Grignard Reaction;

Steps:

6.3

A 100 mL 3 -neck flask was placed under N2 and equipped with a condenser and an addition funnel. Magnesium (2.0 g, 83 mmol) were added, bromo-3-chloro- 5-fluoro benzene (15 g, 72.5 mmol) was taken up in dry THF (70 mL), and transferred to the addition funnel. The Grignard reaction was initiated with approximately 2 mL of the bromo-3-chloro -5-fluorobenzene solution and iodine. The remaining bromo-3-chloro-5-fluorobenzene solution was added and the reaction was refluxed 1 hour.

References:

WO2008/156817,2008,A2 Location in patent:Page/Page column 150-151