ChemicalBook CAS DataBase List 3-Chloro-5-hydroxybenzoic acid methyl ester

3-Chloro-5-hydroxybenzoic acid methyl ester synthesis

6synthesis methods

Product Name:3-Chloro-5-hydroxybenzoic acid methyl ester
CAS Number:98406-04-3
Molecular formula:C8H7ClO3
Molecular Weight:186.59

67-56-1 Synthesis

67-56-1
740 suppliers
$9.00/25ml

53984-36-4 Synthesis

53984-36-4
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$16.00/100mg

3-Chloro-5-hydroxybenzoic acid methyl ester

98406-04-3
51 suppliers
$97.00/100mg

Yield:98406-04-3 99%

Reaction Conditions:

with sulfuric acid for 5.5 h;Heating / reflux;

Steps:

2.1

Preparation 2 3-chloro-5-hydroxybenzyl acetate (33, FIG. 13) Step 1: Methylation of 28 to Give 29. Concentrated sulfuric acid (0.04 mL, 0.48 mmol) was added to a solution of 3-chloro-5-hydroxy-benzoic acid (28, 500 mg, 2.9 mmol) in MeOH (3.5 mL) and the resulting solution was heated at reflux for 5.5 h. The reaction was allowed to cool to rt then partitioned between saturated aqueous NaHCO₃(50 mL) and EtOAc (50 mL). The phases were separated and the aqueous phase was extracted with EtOAc (2×20 mL). The combined organic phases were washed with brine (20 mL), dried (MgSO₄), filtered and concentrated in vacuo to afford 540 mg (99%) of ester 29.

References:

US2008/58414,2008,A1 Location in patent:Page/Page column 20

408492-29-5 Synthesis