![](/CAS/GIF/5344-44-5.gif)
3-chloro-5-nitro-aniline synthesis
- Product Name:3-chloro-5-nitro-aniline
- CAS Number:5344-44-5
- Molecular formula:C6H5ClN2O2
- Molecular Weight:172.57
![1-chloro-3,5-dinitrobenzene](/CAS/GIF/618-86-0.gif)
618-86-0
20 suppliers
inquiry
![3-chloro-5-nitro-aniline](/CAS/GIF/5344-44-5.gif)
5344-44-5
50 suppliers
inquiry
Yield: 84%
Reaction Conditions:
with diammonium sulfide in ethanol;water for 1 h;Heating / reflux;
Steps:
1 Example 1
Synthesis of 5-(R)-(4-bromobenzyl)-3-(3-chloro-5-nitrophenyl)-5-methylimidazoline-2,4-dione
The above product (0.50 g, 2.47 mmol) was refluxed 1 hr in 6 mL alcohol and 3 mL 20% ammonium sulfide in H2O. Water was added and the product was filtered, dried and flash chromatographed on silica gel eluting with 10% acetone-pet ether to obtain 3-chloro-5-nitroaniline (0.36 g, 84%) as an orange powder.
References:
Boehringer Ingelheim Pharmaceuticals, Inc. US6353013, 2002, B1 Location in patent:Page column 28
![3,5-DINITROANILINE](/CAS/GIF/618-87-1.gif)
618-87-1
6 suppliers
$90.00/1g
![3-chloro-5-nitro-aniline](/CAS/GIF/5344-44-5.gif)
5344-44-5
50 suppliers
inquiry
![1,3-Dinitrobenzene](/CAS/GIF/99-65-0.gif)
99-65-0
4 suppliers
$31.39/442244
![3-chloro-5-nitro-aniline](/CAS/GIF/5344-44-5.gif)
5344-44-5
50 suppliers
inquiry
![Ethanol](/CAS/GIF/64-17-5.gif)
64-17-5
706 suppliers
$10.00/50g
![1-chloro-3,5-dinitrobenzene](/CAS/GIF/618-86-0.gif)
618-86-0
20 suppliers
inquiry
![Hydrogen Sulfide](/CAS/GIF/7783-06-4.gif)
7783-06-4
69 suppliers
$133.00/25ml
![Ammonia](/CAS/GIF/7664-41-7.gif)
7664-41-7
491 suppliers
$15.00/100ml
![3-chloro-5-nitro-aniline](/CAS/GIF/5344-44-5.gif)
5344-44-5
50 suppliers
inquiry