3-CHLORO-6-ETHYL-PYRIDAZINE synthesis
- Product Name:3-CHLORO-6-ETHYL-PYRIDAZINE
- CAS Number:98198-61-9
- Molecular formula:C6H7ClN2
- Molecular Weight:142.59
223445-04-3
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98198-61-9
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Yield:98198-61-9 63%
Reaction Conditions:
with hydrogen;palladium 10% on activated carbon in ethyl acetate at 20; for 4 h;
Steps:
19.2
Step 2: 3-Chloro-6-ethyl-pyridazine; [0390] A mixture of 3-chloro-6-vinyl-pyridazine (1 g, 7.09 mmol), palladium on carbon (10% wt, 200 mg) in ethyl acetate (14 mL) under a hydrogen atmosphere was stirred vigorously at ambient temperature for 4 hours. The mixture was then filtered through a pad of celite and the filtrate concentrated onto silica gel and purified via flash column chromatography (SiO2, hexane:ethyl acetate 90:10 - 50:50) to return 3-chloro-6-ethyl- pyridazine as a white solid (627 mg, 63% yield). 1H NMR (CDCl3) δ 1.27 (3H, t), 2.93 (2H, q), 7.72 (IH, d), 7.83 (IH, d). MS m/z=143 (M+H+)+.
References:
WO2008/51808,2008,A2 Location in patent:Page/Page column 115
141-30-0
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557-20-0
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98198-61-9
22 suppliers
$45.00/10mg