3-chloro-6-Methoxy-[1,5]-naphthyridin-4-ol synthesis

3synthesis methods

Product Name:3-chloro-6-Methoxy-[1,5]-naphthyridin-4-ol
CAS Number:724787-12-6
Molecular formula:C9H7ClN2O2
Molecular Weight:210.62

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3-chloro-6-Methoxy-[1,5]-naphthyridin-4-ol

724787-12-6
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Yield:724787-12-6 80%

Reaction Conditions:

with N-chloro-succinimide in acetic acid at 35; for 24 h;

Steps:

1.a

A solution of 6-(methyloxy)-l,5-naphthyridin-4-ol (6-methoxy-lH- [l,5]naphthyridin-4-one, for a synthesis see WO2002096907 Example 1) (50 g; 0.2841 mol) in glacial acetic acid (750 niL) was treated with N-chlorosuccinimide (42.5 g; 0.3185 mol) and the mixture was heated under argon at 35⁰C for 24 hours. It was cooled and the precipitated solid filtered off and washed with a little cold acetic acid, then ether and finally hexane. It was dried at 5O⁰C overnight in vacuo to give an off-white solid 48g (80%). LC/MS (+ve ion electrospray): m/z 209/211 (M+η)⁺

References:

WO2008/6648,2008,A1 Location in patent:Page/Page column 23

6628-77-9 Synthesis

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References

5 - [[(6 - Methoxypyridin - 3 - yl)aMino]Methylidene] - 2,2 - diMethyl - 1,3 - dioxane - 4,6 - dione

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References