ChemicalBook CAS DataBase List 3-Chloro-N,N-diMethylbenzaMide, 97%

3-Chloro-N,N-diMethylbenzaMide, 97% synthesis

6synthesis methods

Product Name:3-Chloro-N,N-diMethylbenzaMide, 97%
CAS Number:24167-52-0
Molecular formula:C9H10ClNO
Molecular Weight:183.63

137-26-8
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$10.00/25g

535-80-8
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$5.00/5g

24167-52-0
28 suppliers
$22.00/250mg

Yield:24167-52-0 95%

Reaction Conditions:

with di-tert-butyl peroxide;copper(I) bromide in ethyl acetate at 120;

Steps:

Typical procedure for the preparation of N-substituted benzamides in the presence of CuBr and DTBP (TP)

General procedure: Benzoic acid (1.0 mml), tetramethylthiuram disulfide (TMTD) (1.1 mmol), CuBr (10% mmol), DTBP (di-tert-butyl peroxide, 2.0 equiv) were added in dried seal tube equipped with a septum and magnetic stirrer bar, EtOAc (ethyl acetate, 2 mL) was then added. The mixture was stirred at 120 ^oC and checked by TLC until the starting material was finished (about 10-12 h). The reaction was cooled down to room temperature, quenched with sat. NH₄Cl solution (5 mL) and then extracted with ethyl acetate (10 mml). The crude solution was dried over anhydrous Na₂SO₄ and evaporated under vacuum. The residue was purified by flash column chromatography to afford the desired product.

References:

Zeng, Meng-Tian;Xu, Wan;Liu, Min;Liu, Xing;Chang, Cai-Zhu;Zhu, Hui;Dong, Zhi-Bing [Synthetic Communications,2017,vol. 47,# 16,p. 1434 - 1440] Location in patent:supporting information

618-46-2 Synthesis