3-(CHLOROACETAMIDOETHYL)INDOLE synthesis
- Product Name:3-(CHLOROACETAMIDOETHYL)INDOLE
- CAS Number:52191-26-1
- Molecular formula:C12H13ClN2O
- Molecular Weight:236.7
61-54-1
501 suppliers
$12.00/5G
79-04-9
354 suppliers
$12.00/5g
52191-26-1
51 suppliers
$75.00/100mg
Yield:52191-26-1 96%
Reaction Conditions:
with triethylamine in tetrahydrofuran at 20; for 6 h;Cooling with ice;Inert atmosphere;
Steps:
6 Example 6 - Synthesis of compound lxg-P-6
In a 50 mL round bottom flask was added 0.8 gCompound 4 and 15 mL of dry tetrahydrofuran,The mixture was stirred in an ice bath under nitrogen,0.48 mL of compound 8 was slowly added dropwise,Followed by the addition of 1.39 mL of triethylamine,The reaction system was stirred at room temperature for 6 hours.Water was added to terminate the reaction,Extracted with ethyl acetate,Washed with water and saturated salt water,The organic phase was separated,Dried over anhydrous magnesium sulfate,After filtration, the solvent was removed by rotary evaporation.To give compound 9 as a white solid,Weighing 1.14 g,Yield 96%.The product was used directly in the next step.
References:
CN105906608,2016,A Location in patent:Paragraph 0058; 0061
61-54-1
501 suppliers
$12.00/5G
79-11-8
10 suppliers
$27.00/25g
52191-26-1
51 suppliers
$75.00/100mg
61-54-1
501 suppliers
$12.00/5G
27243-15-8
76 suppliers
$41.00/100mg
52191-26-1
51 suppliers
$75.00/100mg