3-chlorobicyclo[3.2.1]oct-3-en-2-ol synthesis

Yield:90003-08-0 94.1%

Reaction Conditions:

with benzyltrimethylammonium chloride;potassium hydroxide in water;Reflux;Reagent/catalyst;Concentration;

Steps:

3.2

Embodiments substantially the same manner as in Example 1, difference is that the in Table 1.
Sodium hydroxide 105.2g (2.63mol) was dissolved in 1080mL of water, the addition of 3,4-dichloro-bicyclo [3.2.1] -2-octene 116.4g (0.657mol) and benzyl trimethylammonium chloride 154mg, heating was refluxed overnight, TLC detection reaction process (developing solvent: methylene chloride). Cooling to room temperature, the mixture was extracted with dichloromethane (450mL × 2), the organic layer was washed once with 300mL of water, dried over anhydrous sodium sulfate, and the solvent removed by distillation to give an orange oily liquid product was 96.92g, 93% yield.

References:

CN105693569,2016,A Location in patent:Paragraph 0045; 0046; 0060; 0061