ChemicalBook CAS DataBase List 3-Chloronaphthalene-2-carboxaldehyde

3-Chloronaphthalene-2-carboxaldehyde synthesis

10synthesis methods

Product Name:3-Chloronaphthalene-2-carboxaldehyde
CAS Number:80228-36-0
Molecular formula:C11H7ClO
Molecular Weight:190.63

99852-39-8
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80228-36-0
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Yield:80228-36-0 94%

Reaction Conditions:

with pyridinium chlorochromate in dichloromethane at 0 - 20;Inert atmosphere;

Steps:

A.1.9.2 A.1 .9.2. 3-Chloro-2-naphthaldehyde

To a cooled (0°C) suspension of pyridinium chlorochromate (906 mg, 4.20 mmol) in DCM (10 mL) is added a solution of (3-chloronaphthalen-2-yl)methanol (540 mg, 2.80 mmol) in DCM (25 mL). The resulting black suspension is further stirred at 0°C, under nitrogen, for 15 mm and then at RT overnight. The RM is then filtered over celite and the filtrate is concentrated under reduced pressure. Purification by FC (DCM) affords3-chloro-2-naphthaldehyde as a pale yellow solid (504 mg, 94%). LC-MS A: tR = 0.89 mm; no ionization.

References:

WO2018/210988,2018,A1 Location in patent:Page/Page column 96