3-CHLOROPROPYL ISOTHIOCYANATE synthesis

5synthesis methods

Product Name:3-CHLOROPROPYL ISOTHIOCYANATE
CAS Number:2799-72-6
Molecular formula:C4H6ClNS
Molecular Weight:135.62

333-20-0
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109-70-6 Synthesis

109-70-6
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2799-72-6
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$15.00/500mg

Yield:-

Reaction Conditions:

in tetrahydrofuran at 70; for 3 h;

Steps:

6.2 Step 2: The specific synthesis method for the synthesis of 3-chloroisothiocyanopropane from 1-bromo-3-chloropropane and thiocyanate is:

The thiocyanate was dissolved in 1.2 times its own molar amount of tetrahydrofuran, and heated slowly to 70 ° C at a temperature increase rate of less than 20 ° C / min. The molar ratio of 1-bromo-3-chloropropane to potassium thiocyanate was 1-bromo-3-chloropropane was slowly added dropwise to the potassium thiocyanate solution at 1:1, and the dropwise addition was completed after 1 h. After the completion of the dropwise addition, the original temperature was maintained for 2 h to complete the reaction;1-Bromo-3-chloropropane is reacted with potassium thiocyanate to form 3-chloroisothiocyanopropane and potassium bromide; after the reaction is completed, the reaction solution is cooled, filtered, and distilled under normal pressure or reduced pressure to collect the fraction. The 3-chloroisothiocyanopropane component is ready for use.

References:

CN110143901,2019,A Location in patent:Paragraph 0074; 0078; 0079