3-CHLOROPYRIDAZINE synthesis
- Product Name:3-CHLOROPYRIDAZINE
- CAS Number:1120-95-2
- Molecular formula:C4H3ClN2
- Molecular Weight:114.53
504-30-3
236 suppliers
$6.00/1g
1120-95-2
137 suppliers
$50.00/100 mg
Yield:1120-95-2 92%
Reaction Conditions:
with trichlorophosphate at 60; for 1.5 h;
Steps:
118
Preparation 118: 3-Chloro-pyridazine (Prepi 18); A mixture of pyridazin-3-ol (1.9 g, 19.8 mmol) in POCI3 (19 ml) was heated to 600C for 90 minutes. After cooling to room temperature, the reaction was quenched in ice/water and neutralized with solid NaHCO3. The product was extracted with ethyl acetate, the organic phase was washed with brine, dried (Na2SO4) and evaporated to give 2.1 g of the title compound as a brown solid (92% yield). MS (ES) (m/z): 115.1 [M+H]+.
References:
Glaxo Group Limited WO2007/113232, 2007, A1 Location in patent:Page/Page column 122
504-30-3
236 suppliers
$6.00/1g
1120-95-2
137 suppliers
$50.00/100 mg