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ChemicalBook CAS DataBase List 3-CYANO-3-PHENYLPROPANOIC ACID

3-CYANO-3-PHENYLPROPANOIC ACID synthesis

3synthesis methods
-

Yield:14387-18-9 81%

Reaction Conditions:

Stage #1: chloroacetic acidwith potassium carbonate in N,N-dimethyl-formamide;
Stage #2: phenylacetonitrilewith potassium hydroxide in N,N-dimethyl-formamide at 20 - 25; for 2 h;

References:

Makosza;Marcinowicz [Synthesis,2001,# 9,p. 1311 - 1312]

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