ChemicalBook CAS DataBase List 3-CYANO-5-(METHOXYCARBONYL)BENZOIC ACID

3-CYANO-5-(METHOXYCARBONYL)BENZOIC ACID synthesis

3synthesis methods

Product Name:3-CYANO-5-(METHOXYCARBONYL)BENZOIC ACID
CAS Number:126739-90-0
Molecular formula:C10H7NO4
Molecular Weight:205.17

23340-69-4 Synthesis

23340-69-4
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126739-90-0
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Yield:126739-90-0 43%

Reaction Conditions:

Stage #1: dimethyl 5-cyanoisophthalatewith methanol;sodium hydroxide;water in tetrahydrofuran at 20; for 17 h;
Stage #2: with hydrogenchloride;water in ethyl acetate;

Steps:

11.c

Step c 5-Cvano-isophthalic acid monomethyl ester (1 Ic); A solution of 5-cyano-isophthalic acid dimethyl ester (123 mg, 0.56 mmol) in THF:MeOH (1 :1, 4 rnL) was treated with NaOH (22 mg, 0.56 mmol) in H₂O (0.5 mL) at r.t. The reaction mixture was stirred 17 h and concentrated under vacuum. The residue was taken into EtOAc and 2M HCl, the phases were separated and the organic phase dried (Na₂SO₄). Evaporation of the solvent afforded the title compound (49 mg, 43 %).

References:

WO2008/119772,2008,A1 Location in patent:Page/Page column 72-73

13036-02-7 Synthesis

13036-02-7
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126739-90-0
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References

Dimethyl 5-[[(Trifluoromethyl)sulfonyl]oxy]isophthalate

168619-21-4
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126739-90-0
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References

3-CYANO-5-(METHOXYCARBONYL)BENZOIC ACID Related Search:

5-CYANO-DIMETHYLISOPHTHALATE 5-CYANO-1,3-DIHYDROXYMETHYLBENZENE 3-CYANO-5-METHYL-BENZOIC ACID