3-cyano-N-(4-methoxyphenyl)benzenesulfonamide synthesis

Yield:1004035-01-1 76%

Reaction Conditions:

with pyridine in dichloromethane at 20;

Steps:

4.2.1. Preparation of nitriles B

General procedure: A mixture of 3- or 4-cyanobenzenesulfonyl chloride (605 mg, 3 mmol), the amine (3.3 mmol) and pyridine (736 mg, 9.3 mmol) was stirred overnight at room temperature in abs dichloromethane (40 mL). After removal of the solvent at reduced pressure, nitriles B were obtained by flash column chromatography (dichloromethane) and recrystallisation from ethyl acetate/hexane or toluene.

References:

Dosa, Stefan;Stirnberg, Marit;Luelsdorff, Verena;Haeussler, Daniela;Maurer, Eva;Guetschow, Michael [Bioorganic and medicinal chemistry,2012,vol. 20,# 21,p. 6489 - 6505,17] Location in patent:supporting information