3-Diethylaminophenol synthesis
- Product Name:3-Diethylaminophenol
- CAS Number:91-68-9
- Molecular formula:C10H15NO
- Molecular Weight:165.23
Yield:91-68-9 98.5%
Reaction Conditions:
with sodium amide at 5; for 0.583333 h;
Steps:
2-6 One-step synthesis of m-diethylaminophenol
In a 500ml flask, add 200g of diethylamine, add 10g of catalyst sodium amide and 5g of super-base catalyst, stir and cool to 5°C, dropwise add 15g o-chlorophenol in 15 minutes. Turn on the ultrasonic, the ultrasonic frequency is 40kHz, the ultrasonic power is 100w, the temperature is raised to the diethylamine reflux state, the reaction is 20 minutes, and the reaction is over. Recycle diethylamine by rotary evaporation, add 60g of toluene, add 75g of water dropwise to quench the reaction when the temperature is below 5, add dropwise 5% hydrochloric acid aqueous solution to adjust pH=7, separate, wash with water, separate the liquid, rotate the organic phase to obtain the product The m-diethylaminophenol is 18.9 g, the yield is 98.5%, and the purity is 99.1%.
References:
Anhui Green Gu Chuangke Space Co., Ltd.;Li Fujia;Li Yunzheng;Wan Yuqing CN112142607, 2020, A Location in patent:Paragraph 0016-0020
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