3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)PROPAN-1-OL synthesis
- Product Name:3-(DIMETHYLAMINO)-1-(4-FLUOROPHENYL)PROPAN-1-OL
- CAS Number:133712-56-8
- Molecular formula:C11H16FNO
- Molecular Weight:197.2492
55831-59-9
0 suppliers
inquiry
133712-56-8
7 suppliers
$618.00/1g
Yield:133712-56-8 94%
Reaction Conditions:
with methanol;sodium tetrahydroborate;sodium hydroxide at 20; pH=12 - 13; for 1 h;Cooling with ice;
Steps:
6 Example 6: Preparation of 3-(dimethylamino)-1-(4-fluorobenzene)-1-propanol
General procedure: Example 2
Preparation of 3-(dimethylamino)-1-phenyl-1-propanol
3-dimethylamino-1-phenyl-1-acetone hydrochloride (10.0 g, 50 mmol) was dissolved in methanol (50 mL).
After pH was adjusted to pH=12-13 with sodium hydroxide solution (5%), sodium borohydride (2.3 g, 60 mmol) was added in portions under ice bath.
After addition, the reaction mixture was stirred at room temperature for 1 h.
The reaction liquid was concentrated, added with water (100 mL), extracted with ethyl acetate, washed with water, dried and concentrated to give 7.9 g of 3-(dimethylamino)-1-phenyl-1-propanol as colorless liquid, yield 96%. According to the procedures in Example 2, 31 3-(dimethylamino)-1-(4-fluorobenzene)-1-acetone was reacted with 33 sodium borohydride to give 34 3-(dimethylamino)-1-(4-fluorobenzene)-1-propanol as colorless liquid, yield 94%.
References:
US2017/369466,2017,A1 Location in patent:Paragraph 0066; 0074
3935-51-1
5 suppliers
inquiry
133712-56-8
7 suppliers
$618.00/1g
403-42-9
531 suppliers
$5.00/10g
133712-56-8
7 suppliers
$618.00/1g