3-(Dimethylamino)-1-(4-nitrophenyl)prop-2-en-1-one synthesis
2synthesis methods
- Product Name:3-(Dimethylamino)-1-(4-nitrophenyl)prop-2-en-1-one
- CAS Number:68760-11-2
- Molecular formula:C11H12N2O3
- Molecular Weight:220.22
Yield:68760-11-2 96.8%
Reaction Conditions:
in toluene at 90 - 95; for 12 h;
Steps:
1.1 Example 1
N-(4-(1H-pyrazol-5-yl)phenyl)-2-(2-(3-methyl-4-nitrophenyl)acetamido)-3-phenylpropanamide(1) Addition reaction: 16.50 g (0.10 mol) of 4-nitroacetophenone andN,N-Dimethylformamide dimethyl acetal17.86 g (0.15 mol) dissolved in 10 ml of toluene, and reacted at 90-95°C for 12 h, concentrated under reduced pressure and mixed with a solvent, and allowed to stand at 0°C for 2.5 h, filtered, and dried.3-(N,N-dimethylamino)-1-(4-nitrophenyl)-2-propene-1-one(a) 21.30 g with a yield of 96.8%;
References:
CN107488148,2017,A Location in patent:Paragraph 0025
