3-(DIMETHYLAMINOMETHYL)-6-NITROINDOLE synthesis
- Product Name:3-(DIMETHYLAMINOMETHYL)-6-NITROINDOLE
- CAS Number:6954-87-6
- Molecular formula:C11H13N3O2
- Molecular Weight:219.24
50-00-0
875 suppliers
$10.00/25g
4769-96-4
270 suppliers
$9.00/250mg
124-40-3
523 suppliers
$18.00/100ml
6954-87-6
39 suppliers
$120.00/1g
Yield:6954-87-6 87%
Reaction Conditions:
Stage #1: formaldehyd;dimethyl aminewith acetic acid at 0; for 0.5 h;
Stage #2: 6-nitroindole at 20; for 72 h;
Steps:
3
A solution of dimethylamine (25 g, 0.17 mol) and formaldehyde (14.4 mL, 0.15 mol) in acetic acid (100 mL) was stirred at 0° C. for 30 min. To this solution was added 6-nitro-1H-indole (20 g, 0.12 mol). After stirring for 3 days at room temperature, the mixture was poured into 15% aq. NaOH solution (500 mL) at 0° C. The precipitate was collected via filtration and washed with water to give dimethyl-(6-nitro-1H-indol-3-ylmethyl)-amine (23 g, 87%).
References:
US2012/309758,2012,A1 Location in patent:Page/Page column 70
4769-96-4
270 suppliers
$9.00/250mg
6954-87-6
39 suppliers
$120.00/1g
4769-96-4
270 suppliers
$9.00/250mg
124-40-3
523 suppliers
$18.00/100ml
6954-87-6
39 suppliers
$120.00/1g
4769-96-4
270 suppliers
$9.00/250mg
506-59-2
560 suppliers
$5.00/5G
6954-87-6
39 suppliers
$120.00/1g
