![](/StructureFile/ChemBookStructure3/GIF/CB7692660.gif)
3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE synthesis
- Product Name:3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE
- CAS Number:141210-63-1
- Molecular formula:C11H12N2O
- Molecular Weight:188.23
![Oxindole](/CAS/GIF/59-48-3.gif)
59-48-3
463 suppliers
$5.00/1g
![N,N-Dimethylformamide dimethyl acetal](/CAS/GIF/4637-24-5.gif)
4637-24-5
589 suppliers
$5.00/25g
![3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE](/StructureFile/ChemBookStructure3/GIF/CB7692660.gif)
141210-63-1
13 suppliers
$57.50/250mg
Yield:141210-63-1 93%
Reaction Conditions:
in chloroform at 70; for 4.5 h;
Steps:
1.1
To a solution of 1,3-dihydro-2H-indol-2-one (ii-a, 25.0 g, 189 mmol) in CHCl3 (150 mL) was added N,N-dimethylformamide dimethyl acetal (29.2 mL, 209 mmol) and the reaction was heated at 70° C. under an atmosphere of argon. After 4.5 h, the reaction was cooled to RT and was concentrated. The resulting solid was triturated with ether and filtered to give (3Z)-3-[(dimethylamino)methylene]-1,3-dihydro-2H-indol-2-one as a yellow solid (iii-a, 33.0 g, 93%). NH4OAc QC conditions. DAD Retention Time=1.19 min. M+H=189.
References:
US2007/207997,2007,A1 Location in patent:Page/Page column 34
![Oxindole](/CAS/GIF/59-48-3.gif)
59-48-3
463 suppliers
$5.00/1g
![N,N-Dimethylformamide dimethyl acetal](/CAS/GIF/4637-24-5.gif)
4637-24-5
589 suppliers
$5.00/25g
![(3E)-3-(dimethylaminomethylidene)-1H-indol-2-one](/CAS/20180723/GIF/141210-64-2.gif)
141210-64-2
2 suppliers
inquiry
![3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE](/StructureFile/ChemBookStructure3/GIF/CB7692660.gif)
141210-63-1
13 suppliers
$57.50/250mg
![Oxindole](/CAS/GIF/59-48-3.gif)
59-48-3
463 suppliers
$5.00/1g
![3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE](/StructureFile/ChemBookStructure3/GIF/CB7692660.gif)
141210-63-1
13 suppliers
$57.50/250mg
![3-[(Dimethylamino)methylene]-2-indolinone](/CAS/20180601/GIF/57315-91-0.gif)
57315-91-0
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![3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE](/StructureFile/ChemBookStructure3/GIF/CB7692660.gif)
141210-63-1
13 suppliers
$57.50/250mg
![Oxindole](/CAS/GIF/59-48-3.gif)
59-48-3
463 suppliers
$5.00/1g
![N,N-Dimethyformamide diethy acetal](/CAS/GIF/1188-33-6.gif)
1188-33-6
248 suppliers
$11.19/5ML
![(3E)-3-(dimethylaminomethylidene)-1H-indol-2-one](/CAS/20180723/GIF/141210-64-2.gif)
141210-64-2
2 suppliers
inquiry
![3-DIMETHYLAMINOMETHYLENE-1,3-DIHYDRO-INDOL-2-ONE](/StructureFile/ChemBookStructure3/GIF/CB7692660.gif)
141210-63-1
13 suppliers
$57.50/250mg