3-ETHOXY-2-HYDROXY-BETA-NITROSTYRENE synthesis

Yield:206559-62-8 93%

Reaction Conditions:

with ammonium acetate;acetic acid for 5 h;Reflux;

Steps:

1 Example 1: Synthesis of 2-Hydroxy-1-ethoxy-3-(2-nitrovinyl)benzene

Into a four-necked bottle, 1.1 g of ammonium acetate and 4.64 ml of glacial acetic acid were successively added, stirred, and fully dissolved, and then 1 mmol was added in order.2-Hydroxy-1-ethoxy-3-aldehyde benzeneAnd 4mmol of nitromethane, heated to reflux, reaction 5h, TLC monitoring reaction is completed, the reaction solution was cooled to room temperature, then poured into crushed ice, stirred 0.5h, suction filtration,The orange crystalline compound is 2-hydroxy-1-ethoxy-3-(2-nitrovinyl)benzene; the purity is 95%,Yield 93%.

References:

CN106543131,2017,A Location in patent:Paragraph 0029; 0030; 0031