3-Ethyl-2,3-dihydrobenzothiazol-2-on synthesis

5synthesis methods

Product Name:3-Ethyl-2,3-dihydrobenzothiazol-2-on
CAS Number:6468-14-0
Molecular formula:C9H9NOS
Molecular Weight:179.24

74-96-4 Synthesis

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934-34-9 Synthesis

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6468-14-0
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Yield:6468-14-0 84%

Reaction Conditions:

with potassium hydroxide in tetrahydrofuran at 0 - 20; for 3 h;Reagent/catalyst;Solvent;

Steps:

1.1

(1) 2-hydroxybenzothiazole (1 mol, 151 g), 2-bromoethane (1.1 mol, 120 g) and potassium hydroxide (1 mol, 56) dissolved in 2L of tetrahydrofuran, stirred at 0 ° C for 1 hour, then at room temperature for 2 hours, the reaction is completed, spin fourHydrogen furan solvent, add 2 L of ethyl acetate, wash twice with water, dry over anhydrous sodium sulfate, then EtOAcCrystallization of tert-butyl ether gave 150 g of 3-ethylbenzothiazol-2-one in a yield of 84%

References:

CN108752289,2018,A Location in patent:Paragraph 0018; 0019