3-ETHYNYL-2-HYDROXY-PHENOL synthesis

11synthesis methods

Product Name:3-ETHYNYL-2-HYDROXY-PHENOL
CAS Number:18649-64-4
Molecular formula:C6H4O
Molecular Weight:92.1

40231-01-4 Synthesis

40231-01-4
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18649-64-4
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$45.00/10mg

Yield: 98.9%

Reaction Conditions:

with potassium carbonate in methanol at 20; for 18 h;Cooling with ice;Inert atmosphere;

Steps:

45
Under ice-cooling and nitrogen atmosphere, compound 2-(trimethylsilyl)ethynylfuran (1.25 g, 7.6 mmol, 1.0 eq.) was dissolved in methanol (50 ml), then added potassium carbonate (2.41 g, 17.48 mmol mol, 2.3 eq.). The reaction mixture was stirred at room temperature for 18 hours. The reaction was diluted with 300 ml of water, extracted with dichloromethane, the organic phase was washed with water and brine two or three times, dried over anhydrous sodium sulfate dried dry, spin-dry vacuum solvent to give compound 2-ethynylfuran (693 mg, yield: 98.9%).

References:

Guangzhou Kaisheng Beite Pharmaceutical Co., Ltd.;Cai, Xiong;Qian, Changgeng;Liu, Bin;Li, Junqi;Lin, Mingsheng;Qing, Yuanhui;Weng, Yunwo;Wang, Yanyan;Xue, Weicai;You, Huajin;Zhou, Shiqing CN105622638, 2016, A Location in patent:Paragraph 0376