3-FLUORO-4-METHOXYPHENETHYL ALCOHOL synthesis

Yield:404-91-1 78%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 20; for 1 h;Darkness;

Steps:

1 Step 1. Synthesis of 2-(3-fluoro-4-methoxyphenyl)ethan-1-ol.

2-(3-fluoro-4-methoxyphenyl)acetic acid (400 mg, 2.17 mmol) was dissolved in THF (4 mL). The reaction solution was cooled to 0^oC. Lithium aluminium hydride (90.8 mg, 2.39 mmol) was added portionwise. The flask was then wrapped with aluminum foil and the resulting solution was stirred for 1 h at room temperature. The reaction was then quenched by the addition of 2 mL of water/ice. The resulting mixture was concentrated under vacuum. The solution was extracted with 2x10 mL of ethyl acetate and the organic layers were combined and evaporated. This afforded 290 mg (78%) of 2-(3-fluoro-4-methoxyphenyl)ethan-1-ol as colorless oil.

References:

WO2019/55877,2019,A1 Location in patent:Paragraph 0090