3-Fluoro-4-methylbenzenesulfonamide synthesis

Yield:329909-29-7 100%

Reaction Conditions:

at 20; for 4 h;

Steps:

4 Example 4: preparation of 3-fluoro-4-methyl- benzenesulfonamide 2f

3-Fluoro-4-methylbenzene-1-sulfonyl chloride if (0.5 g, 2.4 mmol) was suspended in concentrated ammonia (10 mL) and the mixture was agitated at room temperature for 4 hours. After the reaction was complete according to TLC (PE/EA = 3/1), the reaction mixture was extracted with ethyl acetate twice (5 x and 10 mL) . The organic layers were combined, washed with water, and saturated brine, dried, and concentrated to provide 3-fluoro-4- methlbenzene-1-sufonamide 2f as a white solid (380 mg, 100% yield) . LC-MS: 190 [M+1].

References:

WO2019/13981,2019,A1 Location in patent:Paragraph 0176; 0177