3-Fluoro-5-methylphenylboronic acid pinacol ester synthesis

5synthesis methods

Product Name:3-Fluoro-5-methylphenylboronic acid pinacol ester
CAS Number:1583286-47-8
Molecular formula:C13H18BFO2
Molecular Weight:236.09

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3-Fluoro-5-methylphenylboronic acid pinacol ester

1583286-47-8
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Yield:1583286-47-8 79%

Reaction Conditions:

with pyridine;cesium fluoride in dimethyl sulfoxide at 105; for 2 h;Inert atmosphere;Schlenk technique;

Steps:

For Solid Aryl Iodides; General Procedure A

General procedure: An oven-dried Schlenk tube, containing a Teflon-coated magnetic stir bar was charged with CsF (228 mg, 1.5 mmol, 3 equiv), bispinacolatodiboron (254 mg, 1 mmol, 2 equiv), and the appropriate aryl iodide (0.5 mmol). Under an argon atmosphere, freshly distilled DMSO (0.4 mL) and pyridine (0.4 to 1 equiv) were added successively using a syringe. The reaction mixture was heated to 105 °C and stirred and stirred for 2 h under argon.

References:

Pinet, Sandra;Liautard, Virginie;Debiais, Mégane;Pucheault, Mathieu [Synthesis,2017,vol. 49,# 21,p. 4759 - 4768]

352-70-5 Synthesis