![](/CAS/GIF/852062-16-9.gif)
3-Fluoro-5-(trifluoromethyl)pyridine-2-carboxamide synthesis
- Product Name:3-Fluoro-5-(trifluoromethyl)pyridine-2-carboxamide
- CAS Number:852062-16-9
- Molecular formula:C7H4F4N2O
- Molecular Weight:208.11
![3-Fluoro-5-trifluoromethyl-pyridine-2-carbonitrile](/CAS/GIF/80194-71-4.gif)
80194-71-4
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![3-Fluoro-5-(trifluoromethyl)pyridine-2-carboxamide](/CAS/GIF/852062-16-9.gif)
852062-16-9
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$198.00/500mg
Yield:852062-16-9 66%
Reaction Conditions:
with sulfuric acid at 105; for 2 h;
Steps:
117
Description 117; 3-Fluoro-5-trifluoromethylpyridine-2-carboxamide; Description 116 (8 g, 42 mmol) was added to stirring conc. H2SO4 (65ml) and the reaction mixture heated at 105°C for 2 hours, then cooled to room temperature and poured onto ice water. The solid which formed was collected by filtration and washed with a little water to give the title compound (5.8 g, 66%). 1H NMR (400 MHz, DMSO-d6) 7.90 (1 H, s), 8. 17 (1 H, s), 8.46 (1 H, d, J 10. 1), 8.88 (1 H, s).
References:
WO2005/47279,2005,A1 Location in patent:Page/Page column 57