3-FLUORO-N-METHYL-4-NITROBENZAMIDE synthesis
- Product Name:3-FLUORO-N-METHYL-4-NITROBENZAMIDE
- CAS Number:658700-20-0
- Molecular formula:C8H7FN2O3
- Molecular Weight:198.15
Yield: 96%
Reaction Conditions:
with 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in methanol;dichloromethane at 20;
Steps:
4
To a solution of [3-FLUORO-4-NITROBENZOIC] acid (4.0 g, 21.6 mmol) and EDC [(1- [3-] (dimethylamino) propyl] -3-ethylcarbodiimide hydrochloride) (4.36 g, 28.1 mmol) in methylene chloride (100 mL) was added methylamine (11.3 mL of a 2 M solution in [MEOH,] 22.7 mmol) and the solution was stirred at room temperature overnight. The solution was washed with 1 N [HCI,] dried over [MGS04] and concentrated to a solid. The solid was triturated with butyl chloride and collected by filtration to give the N-methyl-3- [FLUORO-4-NITROBENZAMIDE] (3. 81 g, 96%).
References:
BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. WO2004/14905, 2004, A1 Location in patent:Page 159-160
157665-51-5
25 suppliers
inquiry
593-51-1
544 suppliers
$21.00/100g
658700-20-0
21 suppliers
inquiry
403-21-4
254 suppliers
$6.00/1g
658700-20-0
21 suppliers
inquiry