3'-FLUOROBIPHENYL-2-CARBALDEHYDE synthesis

5synthesis methods

Product Name:3'-FLUOROBIPHENYL-2-CARBALDEHYDE
CAS Number:676348-32-6
Molecular formula:C13H9FO
Molecular Weight:200.21

17318-03-5
85 suppliers
$60.00/100mg

2-Propanamine, N-[(2-methoxyphenyl)methylene]-2-methyl-

82632-38-0
0 suppliers
inquiry

676348-32-6
24 suppliers
$290.00/1g

Yield:676348-32-6 95%

Reaction Conditions:

Stage #1: N-tert-butyl-1-(2-methoxyphenyl)methaniminewith chromium dichloride in tetrahydrofuran at 25; for 0.0833333 h;Schlenk technique;Inert atmosphere;
Stage #2: bromo(3-fluorophenyl)magnesium in tetrahydrofuran at 25; for 5 h;Schlenk technique;Inert atmosphere;
Stage #3: with hydrogenchloride in tetrahydrofuran;water at 25; for 3 h;Schlenk technique;Inert atmosphere;

References:

Cong, Xuefeng;Tang, Huarong;Zeng, Xiaoming [Journal of the American Chemical Society,2015,vol. 137,# 45,p. 14367 - 14372] Location in patent:supporting information

768-35-4 Synthesis