3-ForMaMido-4-hydroxybenzoic acid, 97% synthesis

Yield:15026-75-2 90%

Reaction Conditions:

in water at 70; for 24 h;

Steps:

4-Carboxy-2-hydroxy-formanilide (9c)

General procedure: Asolution of 4-amino-3-hydroxybenzoic acid (17, 150mg, 1.0 mmol) in formic acid (206 μL, 4.0 mmol) and water (2 mL) was heated at70 °C overnight. After being cooled, the reaction was concentrated in vacuo.The residue was dissolvedin water (2 mL) and neutralized with aqueous saturatedNaHCO₃solution.Concentrationin vacuo,and purification bycolumn chromatography (dichloromethane:methanol = 5:1)gave9c (148 mg, 83%)

References:

Jaikhan, Pattaporn;Buranrat, Benjaporn;Itoh, Yukihiro;Chotitumnavee, Jiranan;Kurohara, Takashi;Suzuki, Takayoshi [Bioorganic and Medicinal Chemistry Letters,2019,vol. 29,# 10,p. 1173 - 1176] Location in patent:supporting information