ChemicalBook CAS DataBase List 3-Hydroxy-4-methoxybenzoic acid

3-Hydroxy-4-methoxybenzoic acid synthesis

11synthesis methods

Product Name:3-Hydroxy-4-methoxybenzoic acid
CAS Number:645-08-9
Molecular formula:C8H8O4
Molecular Weight:168.15

621-59-0 Synthesis

621-59-0
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$9.00/1g

645-08-9
329 suppliers
$10.00/1g

Yield:645-08-9 98%

Reaction Conditions:

with potassium hydroxide;sodium hydroxide in water at 160; for 0.333333 h;

Steps:

3-Hydroxy-4-methoxybenzoic Acid (2)
A mixture of NaOH (1.0 g), KOH (1.5 g), and H2O (0.5 mL) was heated to160C; then isovanillin (1) (3.0 g, 19.74 mmol) was added. The reaction mixture was stirred at 160C for 20 min; 100 mL H2Owas added, and the mixture cooled to room temperature. The solution was acidified with concentrated HCl to pH 2. The solidwas separated by filtration and washed with water to give 2 (3.25 g, 98%).

References:

Shan, Yuanyuan;Lei, Jine;Zhang, Li;Fan, Te;Wang, Maoyi;Ma, Ying [Chemistry of Natural Compounds,2015,vol. 51,# 4,p. 620 - 625][Khim. Prir. Soedin.,2015,vol. 51,# 4,p. 536 - 540,5]

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