3-hydroxycyclopentanecarbonitrile synthesis

3synthesis methods

Product Name:3-hydroxycyclopentanecarbonitrile
CAS Number:194534-83-3
Molecular formula:C6H9NO
Molecular Weight:111.14

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Yield:194534-83-3 95%

Reaction Conditions:

with sodium tetrahydroborate in methanol at 20; for 0.5 h;

Steps:

56.B Step B: 3-hydroxycyclopentanecarbonitrile

To a solution of 3-oxocyclopentanecarbonitrile (4 g, 37 mmol) in methanol (50 mL) at 0 ° C was added sodium borohydride(2 g, 44 mmol) and the reaction system was stabilized at 20-30 ° C. After 30 minutes of reaction at room temperature, the solvent was removed under reduced pressure and the residue was isolated by column chromatography (ethyl acetate / petroleum ether = 1/10) to give the title compound (3.8 g, 95%).

References:

CN107474024,2017,A Location in patent:Paragraph 0479; 0483; 0484; 0485

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194534-83-3
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References

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References