3-Hydroxynaphthalene-2-boronic acid pinacol ester synthesis

5synthesis methods

Product Name:3-Hydroxynaphthalene-2-boronic acid pinacol ester
CAS Number:1437769-83-9
Molecular formula:C16H19BO3
Molecular Weight:270.13

30478-88-7 Synthesis

30478-88-7
80 suppliers
$47.00/250mg

73183-34-3
564 suppliers
$6.00/5g

3-Hydroxynaphthalene-2-boronic acid pinacol ester

1437769-83-9
20 suppliers
$45.00/25mg

Yield:1437769-83-9 83.1%

Reaction Conditions:

with anhydrous potassium acetate;palladium diacetate;dicyclohexyl(2’,4’,6’-triisopropyl-[ 1,1’-bi-phenyl]-2-yl)phosphane in 1,4-dioxane at 95 - 100;Inert atmosphere;

Steps:

Preparation of intermediate B:

200.0 g of Compound A (896.60 mmol, CAS No.: 30478-88-7), 439.97 g of potassium acetate (4.48 mol), 273.22 g of bis(pinacolato)diboron (1.08 mol), 1600.0 g of dioxane, under nitrogen protection, add 2.01 g of palladium acetate (8.97 mmol), X-Phos 8.55 g ( 17.94mmol), the material is added, the heating is 95.0 ~ 100.0 °C, and the heat preservation is 9 ~ 10h. TLC test raw material reaction is completed, reduced to room temperature after adding 1600.0g of toluene, washed to neutral, 95 °C dehydration solvent. Recrystallization with toluene: n-hexane = 3:2. 201.3g of Compound B was obtained, yield 83.1%, purity 99.6%.

References:

CN114057703,2022,A Location in patent:Paragraph 0021-0026

135-19-3 Synthesis