3-hydroxypropanoyl chloride synthesis

Yield:-

Reaction Conditions:

with oxalyl dichloride in dichloromethane

Steps:

266
Example 266 3-Hydroxy-, 3-f4-(3-morpholin-4-yl-3-oxo procenyl)-2,3-bis-trifluoromethyl- phenylsulfanyl] -phenyl}-propionamide; [0533] 3-Hydroxy-propionyl chloride was prepared from 3-hydroxy- propionic acid using oxalyl chloride (2M in CH2C12) and reacted with the product of Example 4 using potassium carbonate to afford the final product after HPLC purification. MS ESI (+) m/z 549 (M+H+).

References:

ICOS CORPORATION;BIOGEN IDEC MA INC. WO2005/105770, 2005, A2 Location in patent:Page/Page column 142