3-iodo-2-phenylimidazo[1,2-a]pyridine synthesis

14synthesis methods

Product Name:3-iodo-2-phenylimidazo[1,2-a]pyridine
CAS Number:64413-90-7
Molecular formula:C13H9IN2
Molecular Weight:320.13

4105-21-9 Synthesis

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Yield:64413-90-7 97%

Reaction Conditions:

with N-iodo-succinimide in acetonitrile at 20; for 5 h;

Steps:

72 Preparation 72; 3-iodo-2-phenylimidazo [1, [2-A] PYRIDINE]

Treat a solution of 2-phenylimidazo [1, 2-a] pyridine (50 mg, 0.257 mmol) in acetonitrile (1.25 [ML)] with N-iodosuccinimide (NIS) (69 mg, 0.309 mmol) at room temperature for 5 hours. Dilute the mixture with ether (10 mL), wash with a saturated aqueous solution [OF NAHC03] (15 [ML)] and [NAHS03] [(40%,] 15 mL), dry [(NA2S04)] and concentrate in vacuo. A yellow solid is obtained, 80 mg, 97% yield. MS [(ES+)] : [FNLZ =] 321.0 (M+H) [+]

References:

WO2004/14900,2004,A1 Location in patent:Page 43