3-IODO-IMIDAZO[1,2-A]PYRIDINE-8-CARBONITRILE synthesis

Yield:885276-26-6 80%

Reaction Conditions:

with N-iodo-succinimide in dichloromethane;

Steps:

12 Synthesis of 3-iodoimidazo [1 ,2-a]pyridine-8 -carbonitrile

Synthesis of 3-iodoimidazo [1 ,2-a]pyridine-8 -carbonitrile. To a stuffed solution of imidazo[1,2-a]pyridine-8-carbonitrile (1.2 g, 8.38 mmol) in dichloromethane (10 mL) was added N-iodosuccinimide (1.89 g, 8.38 mmol). LCMS monitored the reaction until the starting material consumed completely. The reaction mixture was dilutedwith dichloromethane and water. The separated organic layer was dried sodium sulfate, filtered and concentrated to give 3-iodoimidazo[1,2-a]pyridine-8-carbonitrile (1.8 g, 6.69 mmol, 80 % yield) as a brown solid. MS (ES+) C8H81N3 requires: 269, found: 270 [M + H].

References:

WO2014/11900,2014,A2 Location in patent:Page/Page column 90; 91