3-iodo-N-methylbenzamide synthesis

6synthesis methods

Product Name:3-iodo-N-methylbenzamide
CAS Number:90434-01-8
Molecular formula:C8H8INO
Molecular Weight:261.06

74-89-5 Synthesis

74-89-5
7 suppliers
$13.44/25ML

618-51-9
380 suppliers
$9.00/10g

90434-01-8
19 suppliers
$30.00/250mg

Yield:90434-01-8 200 mg

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine;HATU in tetrahydrofuran;N,N-dimethyl-formamide at 20;

Steps:

55.2 2. Synthesis of Intermediate 55-2

To a solution of methyl 3-iodobenoic acid (250.0 mg, 0.81 mmol, 1.0 equiv) in DMF (3.0 mL) were added methylamine (0.6 mL, 1.2 mmol, 1.5 equiv, 2M/THF), HATU (368 mg, 1.0 mmol, 1.2 equiv.), and DIEA (208 mg, 1.6 mmol, 2.0 equiv.). The mixture was stirred at rt overnight, diluted with water, and extracted with EA (20 mL). The organic layer was washed with brine twice, dried over Na₂S0₄, concentrated under reduced pressure, and purified by silica gel column chromatography using PE/EA (4/1) as eluent to afford 200 mg of 3 - i o do - - m c t h y 1 b c n z a m i dc (Intermediate 55-2) as an off-white solid. LRMS (ES) m/z 262 (M+H).

References:

WO2020/47447,2020,A1 Location in patent:Paragraph 0526

593-51-1 Synthesis