3-iodo-N-methylbenzamide synthesis
- Product Name:3-iodo-N-methylbenzamide
- CAS Number:90434-01-8
- Molecular formula:C8H8INO
- Molecular Weight:261.06
74-89-5
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90434-01-8
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$30.00/250mg
Yield:90434-01-8 200 mg
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine;HATU in tetrahydrofuran;N,N-dimethyl-formamide at 20;
Steps:
55.2 2. Synthesis of Intermediate 55-2
To a solution of methyl 3-iodobenoic acid (250.0 mg, 0.81 mmol, 1.0 equiv) in DMF (3.0 mL) were added methylamine (0.6 mL, 1.2 mmol, 1.5 equiv, 2M/THF), HATU (368 mg, 1.0 mmol, 1.2 equiv.), and DIEA (208 mg, 1.6 mmol, 2.0 equiv.). The mixture was stirred at rt overnight, diluted with water, and extracted with EA (20 mL). The organic layer was washed with brine twice, dried over Na2S04, concentrated under reduced pressure, and purified by silica gel column chromatography using PE/EA (4/1) as eluent to afford 200 mg of 3 - i o do - - m c t h y 1 b c n z a m i dc (Intermediate 55-2) as an off-white solid. LRMS (ES) m/z 262 (M+H).
References:
WO2020/47447,2020,A1 Location in patent:Paragraph 0526
593-51-1
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618-51-9
380 suppliers
$9.00/10g
90434-01-8
19 suppliers
$30.00/250mg
1711-10-0
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74-89-5
7 suppliers
$13.44/25ML
90434-01-8
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$30.00/250mg
1197171-76-8
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90434-01-8
19 suppliers
$30.00/250mg
96-31-1
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618-51-9
380 suppliers
$9.00/10g
90434-01-8
19 suppliers
$30.00/250mg