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3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol synthesis
- Product Name:3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol
- CAS Number:771510-25-9
- Molecular formula:C9H11N3O2
- Molecular Weight:193.2025
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
737 suppliers
$5.00/25g
![4-Isopropyl-1H-pyrazol-3-amine](/CAS/GIF/151521-49-2.gif)
151521-49-2
122 suppliers
$21.00/100mg
![3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol](/CAS/20180703/GIF/771510-25-9.gif)
771510-25-9
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Yield:771510-25-9 85%
Reaction Conditions:
with potassium etoxide in ethanol; for 12 h;Reflux;Inert atmosphere;
Steps:
22.3 Step 3: Synthesis of 3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol
Isopropyl-lH-pyrazol-3-amine (5.0 g, 40.0 mmol) followed by diethyl malonate (6.50 ml, 43.1 mmol) were added to a solution of NaOEt freshly prepared by dissolving sodium (0.98 g, 42.8 mmol) in ethanol (100 mL). The resulting mixture was heated under reflux for 12 hours, cooled down to room temperature, concentrated and diluted with water (60 mL); pH was adjusted to 3 with aqueous 2N HC1 solution to render a precipitate which was collected by filtration, washed with water (50 mL X 3) and dried under vacuum to give the 3- isopropylpyrazolo[l,5-a]pyrimidine-5,7-diol (6.6 g, 85 % yield) as off-white solid. ESI- LCMS (m/z): 194.3[M+1]+.
References:
WO2016/44650,2016,A1 Location in patent:Paragraph 00195
![4-Isopropyl-1H-pyrazol-3-amine](/CAS/GIF/151521-49-2.gif)
151521-49-2
122 suppliers
$21.00/100mg
![Diethyl malonate](/CAS/GIF/105-53-3.gif)
105-53-3
737 suppliers
$5.00/25g
![3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol](/CAS/20180703/GIF/771510-25-9.gif)
771510-25-9
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![3-Methylbutanenitrile](/CAS/GIF/625-28-5.gif)
625-28-5
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$82.00/5g
![3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol](/CAS/20180703/GIF/771510-25-9.gif)
771510-25-9
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![2-forMyl-3-Methylbutanenitrile](/CAS/GIF/771510-15-7.gif)
771510-15-7
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![3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol](/CAS/20180703/GIF/771510-25-9.gif)
771510-25-9
18 suppliers
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![4-Isopropyl-1H-pyrazol-3-amine](/CAS/GIF/151521-49-2.gif)
151521-49-2
122 suppliers
$21.00/100mg
![3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol](/CAS/20180703/GIF/771510-25-9.gif)
771510-25-9
18 suppliers
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