3-Isoxazoleaceticacid,4-cyano-5-methyl-(9CI) synthesis

6synthesis methods

Product Name:3-Isoxazoleaceticacid,4-cyano-5-methyl-(9CI)
CAS Number:93276-75-6
Molecular formula:C7H6N2O3
Molecular Weight:166.1341

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3-Isoxazoleaceticacid,4-cyano-5-methyl-(9CI)

93276-75-6
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Yield:-

Steps:

Multi-step reaction with 5 steps
1: 47 percent / thionyl chloride / 3 h / Heating
2: 1.) Mg / 1.) CCl₄ / 1.) benzene, ethanol, reflux, 2.) dioxane, 35-45 deg C
3: 62 percent / hydroxylamine hydrochloride / ethanol / 3 h / Heating
4: 1.) cc H₂SO₄, 2.) sodium acetate / 1.) acetic acid, reflux, 15 min, 2.) 80 deg C, evaporation
5: 94 percent / sodium hydroxide / H₂O

References:

Doleschall, Gabor;Seres, Peter [Journal of the Chemical Society. Perkin transactions I,1988,p. 1875 - 1880]